Synthesis and evaluation of novel, selective, functionalized γ-butyrolactones as sigma-2 ligands
نویسندگان
چکیده
The sigma-2 (σ2) receptor was discovered nearly 40 years ago and recently identified as the Transmembrane Protein 97 (TMEM97, also known MAC30 (Meningioma-associated protein)). Aberrant σ2 activity has been linked to diseases conditions such schizophrenia, Alzheimer’s disease, neuropathic pain, traumatic brain injury, cancer. utility of a therapeutic target is currently under investigation in numerous laboratories. Herein, we report on synthesis evaluation series novel, functionalized γ-butyrolactones that are potent ligands.
منابع مشابه
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ژورنال
عنوان ژورنال: Medicinal Chemistry Research
سال: 2022
ISSN: ['1554-8120', '1054-2523']
DOI: https://doi.org/10.1007/s00044-021-02831-5